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POSTER PRESENTATION / TAM METİN POSTER SUNUM

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Investigation of the Efficacy of Morus Alba Ethanolic Extract
Against Liver Damage Induced by Streptozotocin-Induced Diabetes

Burcu YEŞİLTEPE 1 Haki KARA Alper Serhat KUMRU Mahmut ŞAHİN 1
1
1,*

1 Sivas Cumhuriyet University, Faculty of Veterinary Medicine, Department of Pharmacology
and Toxicology, Sivas, TÜRKIYE

*Correspound Author: askumru@cumhuriyet.edu.tr

Abstract
Streptozotocin (STZ) is a compound with antimicrobial properties that is commonly

used to experimentally induce diabetes. In this study, it was aimed to evaluate the

protective effect of the ethanolic extract of Morus alba (MA) against liver damage induced
by diabetes in male Wistar albino rats, following a single intraperitoneal (i.p.)

administration of STZ at a dose of 55 mg/kg. A total of 24 rats were used and divided into
four groups: control, STZ-only group, STZ + 2 mg/kg/day MA group, and STZ + 4

mg/kg/day MA group. Treatment with Morus alba was continued for 15 consecutive days.
At the end of the 15 day, the rats were euthanized via decapitation, and liver samples
th
were collected. Portions of the liver tissues were reserved for histopathological

examination, while the remaining samples were used to assess serum levels of ALT, AST,
and ALP. Biochemical analysis revealed increased levels of ALT, AST, and ALP in the STZ

group, whereas both MA-treated groups exhibited reductions in these enzyme levels. The
reduction was more pronounced in the group treated with 4 mg/kg MA. Histopathological

evaluation showed severe necrotic and moderate hydropic degeneration of hepatocytes in
the STZ-only group, while these alterations were observed to be mild in the group treated

with 4 mg/kg MA. According to immunohistochemical findings, strong immunopositivity
was observed in the STZ group, whereas moderate and mild immunopositivity were

detected in the 2 mg/kg and 4 mg/kg MA-treated groups, respectively.
In conclusion, the ethanolic extract of Morus alba demonstrated a protective and

restorative effect against STZ-induced liver damage associated with diabetes, with a more

prominent efficacy observed at the 4 mg/kg dosage.
Keywords: Streptozotocin, liver damage, Morus alba.

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