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ORAL PRESENTATION / SÖZLÜ SUNUM

Pharmacokinetics of Levamisole at Various Periods of Pregnancy in Sheep

Kamil UNEY Pedro MARIN Murat YUKSEL Duygu Durna CORUM Erdinc TURK
1
4
3
4
2
Devran COSKUN Hatice Rumeysa CEYHAN * Elena BADILLO Orhan CORUM
6,
5
4
2

1 Selcuk University, Faculty of Veterinary Medicine, Department of Pharmacology and
Toxicology, Konya, TÜRKIYE
2 Murcia University, Faculty of Veterinary Medicine, Department of Pharmacology, Murcia, SPAIN
3 Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics
and Gyneacology, Hatay, TÜRKIYE
4 Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of
Pharmacology and Toxicology, Hatay, TÜRKIYE
5 Siirt University, Faculty of Veterinary Medicine, Department of Pharmacology and
Toxicology, Siirt, TÜRKIYE
6 Osmaniye Korkut Ata University, Health Services Vocational School, Department of
Veterinary Medicine, Osmaniye, TÜRKIYE

*Correspound Author: Rumeysaceyhannn@gmail.com

This study aimed to determine the pharmacokinetics of levamisole at various periods
of pregnancy in sheep. Pharmacokinetic assessments were performed on days 45, 90, and
135 of gestation to represent different physiological stages during pregnancy. The
experiment involved a total of 12 sheep: 6 controls and 6 pregnant animals. Levamisole was
administered via intramuscular injection at a dose of 7.5 mg/kg. Blood samples were
collected at 14 time points over a 72-hour period post-administration. Plasma levamisole
concentrations were analyzed using high-performance liquid chromatography with UV
detection, and pharmacokinetic parameters were calculated through non-compartmental
analysis. No significant differences in pharmacokinetic parameters were observed across
different time points in the control group. In pregnant sheep, pharmacokinetic parameters
were similar to controls on day 45 of pregnancy; however, significant alterations were
observed by day 90 and 135, including changes in t1/2ʎz (except at 90 days), AUC0-∞, ClT/F,
Vdarea/F, and Cmax. At various periods of pregnancy, pharmacokinetic parameters varied
across days 45, 90, and 135. Specifically, compared to day 45, days 90 and 135 showed
increased values of ClT/F and Vdarea/F, while AUC0-∞, Cmax, and t1/2ʎz (except at 90 days)
decreased. There were no notable differences in Tmax between groups. These findings
suggest that, during late pregnancy, levamisole clearance increases, and systemic exposure
decreases in sheep. Pharmacodynamic studies are necessary to evaluate how these
pregnancy-related pharmacokinetic changes translate to clinical effects.
Keywords: Levamisole, Pregnancy, Pharmacokinetics, Sheep.
Acknowledgement: This project supported by The Coordination of Scientific Research
Projects, University of Selcuk, Turkiye (Project No: 24401133).
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