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POSTER PRESENTATION / POSTER SUNUM

Evaluation of the Pharmacological Activities of
Bioactive Compounds in Medicinal and Wild Mushrooms

Melike Betül TAN

Kırıkkale University, Faculty of Veterinary Medicine, Department of Pharmacology and
Toxicology, Kırıkkale, TÜRKIYE

Correspound Author: melikebetultan@gmail.com

This study addresses the health effects of the bioactive compounds contained in

medicinal mushrooms (polysaccharides, phenolic compounds, terpenes, sterols, etc.) and
the pharmacological activity potential of commonly used species. Literature reviews

demonstrate that these mushrooms possess antibacterial, antiviral (particularly against HIV
and HPV infections), antioxidant, anti-inflammatory, anticancer, hepatoprotective,

neuroprotective, immunomodulatory, and antidiabetic activities. Ganoderma lucidum

(Reishi) stands out with its immune-enhancing and tumor-suppressing properties; Lentinula
edodes (Shiitake), through its bioactive compound AHCC, shows promising results in high-

risk HPV infections; Grifola frondosa (Maitake) provides antimetastatic effects via its D-
fraction; and Hericium erinaceus (Lion’s Mane) stimulates nerve growth factor, drawing

attention in the treatment process of neurodegenerative diseases such as Alzheimer’s and
Parkinson’s. Trametes versicolor (Turkey Tail) is evaluated as a supportive agent in cancer

therapy through its polysaccharide-protein complexes (PSK, PSP). In addition, wild species

such as Morchella esculenta (Morel), Amanita caesarea (Caesar’s mushroom), and
Cantharellus cibarius (Chanterelle) provide antitumoral, antioxidant, and metabolism-

regulating effects along with their high nutritional value. Overall, the rich bioactive
compounds of medicinal and wild mushrooms carry great potential both nutritionally and

pharmacologically, and within the scope of clinical research outcomes, they are foreseen to
be considered as complementary therapeutic agents in modern medicine.

Keywords: Wild mushroom, bioactive compound, immunomodulation, complementary
therapy, anticancer, neuroprotective.

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