Page 107 - congress

ORAL PRESENTATION / SÖZLÜ SUNUM

Choline as Essential Nutrient and Neurotoxicity

Bilge Su SARI * Hüseyin GÜNGÖR
1,
2

1 Sivas Cumhuriyet University, Institute of Health Sciences, Department of Veterinary
Pharmacology and Toxicology, Sivas, TÜRKIYE
2 Dokuz Eylül University, Faculty of Veterinary Medicine, Department of Veterinary

Pharmacology and Toxicology, İzmir, TÜRKIYE

*Correspound Author: bsusari3007@gmail.com

Choline, which is necessary for methyl metabolism, neurotransmitter synthesis,
structural integrity of cell membranes and signal transduction functions, is a nutritional

source of both animal and plant origin. Choline serves three fundamental physiological roles:
it facilitates cholinergic neurotransmission, serves as a precursor for the biosynthesis of key

membrane phospholipids such as phosphatidylcholine and sphingomyelin, and functions as
a methyl group donor through its metabolite betaine, thereby contributing to essential

methylation processes.
The methyl donating function of choline is of great importance in maintaining the

balance of cellular antioxidant defense systems. Thus, the cell's struggle with oxidative stress
and its death (apoptosis) are controlled.

Many studies conducted since the 1980’s have revealed the accelerating effect of the

box on the synthesis and release of acetylcholine, an important neurotransmitter in nerve
cells. Following these findings, the Institute of Medicine (IOM) officially recognized choline as

an essential nutrient in 1998. Its prominent role in neurological functions has proven critical
in reducing memory loss and protecting the nervous system. A study examining postmortem

brain samples from Alzheimer’s patients reported significantly reduced levels of
acetylcholine.

In addition, choline plays a vital role in preventing neural tube defects, which are among

the congenital anomalies, and in supporting protective mechanisms against neurotoxicity in
general. In this context, it is emphasized that choline supplementation is especially
important for the sustainability of nervous system development and functions.

Keywords: Alzheimer, Choline, Memory Development, Neurotoxicity.

104