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ORAL PRESENTATION / SÖZLÜ SUNUM

Investigation of the embryotoxic Effects of
Prunus amygdalus var. Amara Seed in Fertile Chicken Eggs

Büşra ŞEN¹ Hasan AYDIN
2,*

¹Faculty of Pharmacy, Adıyaman University, TÜRKİYE
2 Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Adiyaman University, TÜRKİYE

*Correspound Author: haydin@adiyaman.edu.tr

Prunus amygdalus var. Amara seeds (PAS), also known as bitter almonds, contain

amygdalin, a cyanide found in nature. Amygdalin is used in the treatment of anemia, asthma,

hypertension, arteriosclerosis, diabetes, migraine, and cancer. Furthermore, enzymatic
activity from amygdalin can produce toxic hydrogen cyanide. This study aimed to investigate

the embryotoxic effects of PAÇ in fertile chicken eggs morphometrically. To investigate the

embryotoxic effects of PAÇ in fertile eggs, five groups were formed: Group I (Control), Group

II (Distilled Water), Group III (PAÇ-2), Group IV (PAÇ-4), and Group V (PAÇ-8). Five eggs were
used for each group. A water extract of PAS was injected into the air chambers of fertile

chicken eggs weighing an average of 60-70 grams at doses of 2, 4, and 8 g/kg. Fertile

chicken eggs placed in the incubator were incubated for 14 days at 37.5 ºC ambient
temperature and 55-60% humidity. Eggs in each group were hatched on day 14 of

incubation. All embryos were weighed using a precision scale. The crown-rump distances of

the embryos were measured, and a one-way analysis of variance was performed to evaluate
their effects on morphological parameters. The analysis of variance revealed no statistically

significant difference between the groups (P>0.05). PAS did not show significant toxicity on

the embryo in terms of morphological parameters. Further biochemical and

histopathological studies are needed to investigate the embryotoxic effects of PAS.

Keywords: Amygdalin, Embryotoxicity, Fertilized chicken eggs, Prunus Amygdalus var.

Amara.

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