Page 185 - congress

POSTER PRESENTATION / POSTER SUNUM

Endocrine Disrupters: In Vitro and In Vivo Models

Hikmet Özgün İŞCAN Abdurrahman AKSOY
*

Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine,

Ondokuz Mayıs University, Samsun, Türkiye

*Correspound Author: hikmetozgun.iscan@omu.edu.tr

Endocrine disruptors (EDs) are chemicals that can cause developmental, reproductive,
neurological, and immune system disorders by affecting hormonal systems. Chemicals such

as bisphenols, phthalates, dioxins, polybrominated flame retardants, pesticides, industrial
solvents, and polychlorinated biphenyls (PCBs), to which people are commonly exposed in

daily life, can have adverse effects on human, animal, and environmental health. EDs can
directly or indirectly influence processes such as the synthesis, secretion, transport, and

receptor interactions of endogenous hormones. Endocrine disruptors exert their effects

through various mechanisms, such as disrupting the function of thyroid hormone receptors,
inducing oxidative stress, causing neurological disorders, and leading to metabolic problems.

Widespread exposure to these chemicals is considered a significant risk factor for public
health. The undesirable effects of EDs are investigated using both in vivo and in vitro

methods. In vitro models primarily examine receptor and gene expression in cells, whereas
in vivo models investigate the effects of EDs on development, reproduction, and the nervous

system in animals such as mice, zebrafish, and amphibians. The data obtained from these

models enable a multidimensional understanding of the pathophysiological effects of EDs
on biological systems and facilitate realistic risk analyses for human health. Comprehensive

scientific studies are needed to better understand the long-term effects of endocrine
disruptors (EDs) on human health and ecosystems. In this presentation, the experimental in

vitro and in vivo models used to evaluate the toxicological and physiological effects of
endocrine disruptors, as well as the methods specific to these models, will be discussed in

detail.
Keywords: Experimental animal models, endocrine disruptors, endocrine system, in vitro

techniques.

182