Page 66 - congress

ORAL PRESENTATION / TAM METİN SÖZLÜ SUNUM

Li Y, Wang Z, Li Y, Du J, Gao X, Li Y, Lai L. (2024). A combination of machine learning and PBPK
modeling approach for pharmacokinetics prediction of small molecules in humans.
Pharmaceutical Research, 41(7), 1369-1379.
Lin W, Chen Y, Unadkat JD, Zhang X, Wu D, Heimbach T. (2022). Applications, Challenges, and
Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic
Perspective: Lin et al. Pharmaceutical Research, 39(8), 1701-1731.
Lin Z, Gehring R, Mochel J, Lave T, Riviere J. (2016). Mathematical modeling and simulation in animal
health–Part II: principles, methods, applications, and value of physiologically based
pharmacokinetic modeling in veterinary medicine and food safety assessment. Journal of
Veterinary Pharmacology and Therapeutics, 39(5), 421-438.
MATLAB (2025). Erişim tarihi: 28.05.2025 05:41. Erişim adresi:
https://uk.mathworks.com/matlabcentral/fileexchange/37132-physiologically-based-
pharmacokinetic-pbpk-model-for-simbiology.
Ning M, Fang M, Shah K, Dixit V, Pade D, Musther H, Neuhoff S. (2025). A cross-species assessment
of in silico prediction methods of steady-state volume of distribution using Simcyp simulators.
Journal of Pharmaceutical Sciences, 114(2), 1410-1422.
Paini A, Leonard JA, Joossens E, Bessems J, Desalegn A, Dorne,J-L, Gosling JP, Heringa M, Klaric M,
Kliment T. (2019). Next generation physiologically based kinetic (NG-PBK) models in support
of regulatory decision making. Computational Toxicology, 9, 61-72.
Paul P, Colin PJ, Musuamba Tshinanu F, Versantvoort C, Manolis E, Blake K. (2025). Current use of
physiologically based pharmacokinetic modeling in new medicinal product approvals at EMA.
Clinical Pharmacology & Therapeutics, 117(3), 808-817.
Perry C, Davis G, Conner TM, Zhang T. (2020). Utilization of physiologically based pharmacokinetic
modeling in clinical pharmacology and therapeutics: an overview. Current Pharmacology
Reports, 6, 71-84.
PK-Sim (2025). Erişim tarihi: 28.05.2025 05:39. Erişim adresi: https://www.open-systems-
pharmacology.org.
Prieto Garcia L, Lundahl A, Ahlström C, Vildhede A, Lennernäs H, Sjögren E. (2022). Does the choice
of applied physiologically‐based pharmacokinetics platform matter? A case study on
simvastatin disposition and drug–drug interaction. CPT: pharmacometrics & systems
pharmacology, 11(9), 1194-1209.
Raghuvanshi N, Johri A, Saxena M. (2025). Chapter Cheminformatics and Computational Chemistry
in the Drugs & Pharmaceutical Industry. In. Bharti Publication.
Sarvepalli S, Vadarevu S. (2025). Role Of Artificial Intelligence In Cancer Drug Discovery And
Development. Cancer Letters, 217821.
Shebley M, Sandhu P, Emami Riedmaier A, Jamei M, Narayanan R, Patel A, Peters SA, Reddy VP,
Zheng M, de Zwart L. (2018). Physiologically based pharmacokinetic model qualification and
reporting procedures for regulatory submissions: a consortium perspective. Clinical
Pharmacology & Therapeutics, 104(1), 88-110.
Simbiology (2025). Erişim tarihi: 28.05.2025 05:43. Erişim adresi:
https://uk.mathworks.com/products/simbiology.html.
Simcyp PBPK Simulator (2025). Erişim tarihi: 28.05.2025 05:40. Erişim adresi:
https://www.certara.com/software/simcyp-pbpk/?utm.

63