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ORAL PRESENTATION / TAM METİN SÖZLÜ SUNUM

The Protective Role of Antioxidants Against Gentamicin-Induced Nephrotoxicity

Salih DAĞ 1,* Pınar PORTAKAL 2

1 Çankırı Karatekin University, Graduate School of Education, Çankırı, TÜRKIYE
2 Çankırı Karatekin University, School of Food and Agriculture, Çankırı, TÜRKIYE

*Correspound Author: 248411005@ogrenci.karatekin.edu.tr

Abstract

Gentamicin is a potent aminoglycoside antibiotic widely used in the treatment of Gram-

negative bacterial infections. However, despite its therapeutic efficacy, the potential for
renal damage associated with its use is considered a significant limiting factor in clinical

practice. This toxicity is particularly associated with cellular and molecular mechanisms such
as oxidative stress, inflammation, and apoptosis. Recent experimental studies have shown

that various natural and synthetic antioxidants have the potential to reduce these harmful
effects. Agents such as quercetin, curcumin, gallic acid, chrysin, naringenin, and ZnO

nanoparticles have been reported to support antioxidant defence systems, suppress
inflammatory signals, and reduce cell death processes. In particular, studies have

emphasised that the combination of 10-HDA and ZnONP reduces kidney damage through a
synergistic effect. This study aims to elucidate the fundamental pathophysiological

mechanisms of gentamicin nephrotoxicity and evaluate the therapeutic potential of

antioxidant agents in this process. The findings suggest that integrating antioxidants into
gentamicin treatment may be an effective strategy for preventing kidney damage.

Keywords: Antioxidants, apoptosis, gentamicin, inflammation, nephrotoxicity, oxidative
stress.

Gentamisin Kaynakli Nefrotoksisiteye Karşi Antioksidanların Koruyucu Rolü

Özet
Gentamisin, Gram-negatif bakteriyel enfeksiyonların tedavisinde yaygın olarak

kullanılan güçlü bir aminoglikozid antibiyotiktir. Ancak terapötik etkinliğine rağmen,
kullanımına bağlı gelişebilecek böbrek hasarı klinik uygulamada önemli bir sınırlayıcı faktör

olarak değerlendirilmektedir. Bu toksisite, özellikle oksidatif stres, inflamasyon ve apoptoz

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