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POSTER PRESENTATION / POSTER SUNUM

Toxicity of Bisphenol A and It’s Analogs

Zehra Kelime KASAKOLU Arda SAĞIR Ayhan FİLAZİ 2
1,*
1

1 Ankara University, Graduate School of Health Sciences, Department of Pharmacology and
Toxicology, Ankara, Türkiye
2 Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and
Toxicology, Ankara, Türkiye

*Correspound Author: zkasakolu@ankara.edu.tr

Bisphenols (BPA, BPF, BPS) are chemical compounds derived from diphenylmethane,

where two phenol rings are linked by a bridging atom. They are widely used in industry. They
are widely used as antioxidants or monomers in the production of polycarbonate plastics,

epoxy resins, and PVC. They are also exposed to pets through food, water, toys, and medical
equipment. BPA's endocrine-disrupting chemical (EDC) properties are well-established and

have been shown to negatively affect reproductive development in the fetal and neonatal

period. BPF and BPS, produced as alternatives after the BPA ban, have been reported to
exhibit similar structural properties and toxic effects, and in some cases, are more persistent

and prone to bioaccumulation than BPA. Metabolically, BPA is well absorbed orally and
detoxified in the liver through glucuronidation and sulfation, while BPS has been found to

have a longer half-life and higher dermal penetration. Even at toxicologically low doses, it
binds to nuclear receptors, causing multiple disruptions in the reproductive, thyroid,

metabolic, neurological, and cardiovascular systems. Studies in domestic animals and

humans have demonstrated an association with obesity, insulin resistance, decreased
fertility, impaired sperm quality, fetal developmental abnormalities, neurodevelopmental

disorders, and hormone receptor signaling disorders. Findings of veterinary importance
indicate that bisphenols can also cause reproductive disorders, offspring developmental

abnormalities, and neurotoxic effects in animal populations. Therefore, reducing bisphenol
exposure, using alternative safe materials, and expanding biomonitoring methods in

veterinary field studies are recommended.
Keywords: Bisphenol A, BPF, BPS, endocrine disruptor, veterinary toxicology, reproductive

toxicity.

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